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This Protropin is a synthetic (man-made) version of human growth hormone (HGH), a naturally occurring substance thats produced by the pituitary gland which primarily stimulates growth in children. it is approved for use in children who have certain conditions which restrict normal growth and development, such as a growth hormone deficiency due to reduced natural HGH production, kidney disease, Prader-Willi Syndrome (PWS), and Turner’s syndrome.this was most often used in adults to treat both growth failure and weight loss caused by acquired immunodeficiency syndrome (AIDS).
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it is a white powder intended for intramuscular or subcutaneous administration by injection after reconstitution with Bacteriostatic Water. With growth hormone therapy in adults, increases in lean body mass and physical performance, and decreases in body fat and waist circumference are seen.
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Protropin (somatrem for injection), is a polypeptide hormone produced by recombinant DNA technology. it has 192 amino acid residues and a molecular weight of about 22,000 daltons. The product contains the identical sequence of 191 amino acids constituting pituitary-derived human growth hormone plus an additional amino acid, methionine, on the N-terminus of the molecule. this is synthesized in a special laboratory strain of E. coli bacteria which has been modified by the addition of the gene for human growth hormone production.
Protropin stimulates skeletal growth in children with growth failure due to a lack of adequate secretion of endogenous growth hormone. Skeletal growth is accomplished at the epiphyseal plates at the ends of a growing bone. Growth and metabolism of epiphyseal plate cells are directly stimulated by growth hormone and one of its mediators, insulin-like growth factor. Serum levels of insulin-like growth factor-l are low in children and adolescents who are growth hormone deficient, but increase during treatment with it. New bone is formed at the epiphyses in response to growth hormone. This results in linear growth until these growth plates fuse at the end of puberty.